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Associate Professor
ANAI, Motonobu
Systems Biology and Medicine
E-mail
anai@lsbm.org
TEL
03-5452-5540
FAX
03-5452-5540
URL
http://www.lsbm.org/site_e/index.html

1992.06
Internal Medicine, University of Tokyo Hospital


1995.04
Chief Researcher, Institute for Adult Diseases, Asahi Life Foundation


1998.04
Department of Metabolic Diseases, Graduate School of Medicine, Univ. of Tokyo(UT)


2000.12
Director, Institute for Adult Diseases, Asahi Life Foundation


2006.04
Associate Professor, RCAST, UT



Research Interests:
We have previously shown that insulin signaling was impaired on insulin effective organs in a genetically diabetic animal model. Environmental factors such as diet or exercise impair insulin signaling in multiple organs within short periods of time even in the genetically normal animals. In addition, we have identified a novel gene APE (Akt phosphorylation enhancer) that interacts with insulin signaling molecule AKT/PKB and analyzed its function. Common diseases such as diabetes, hyperlipidemia, and hypertension are ameliorated by diet therapy and exercises in short periods. In order to understand the molecular basis of these diseases, we elucidate the crosstalk of different signaling pathway regulations by the complex of signaling molecules, and interaction of signaling molecules with cytoskeleton. We are planning to clarify the signaling pathway regulated timely and spatially by localization analysis using biomolecular visualization and specific antibodies, and also clarify the signaling mechanism by vivo using knock-out mouse.

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