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Researcher's Profile

Professor

Takao HAMAKUBO

Quantitative Biology and Medicine

E-mail: hamakubo.qbm.rcast.u-tokyo.ac.jp

Office:

Tel: 03-5452-5231

FAX: 03-5452-5231

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Biography

1987. 04
Instructor, Dept. of Clinical Science and Lab. Medicine, Kyoto University Faculty of Medicine
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1993. 03
Research Instructor, Dept of Biochemistry, Vanderbilt University School of Medicine, USA
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1995. 02
Instructor, Dept of Medical Science, Kyoto University
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1996. 05
Instructor, RCAST, The University of Tokyo (UTokyo)
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1997. 10
Lecturer, RCAST, UTokyo
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1999. 04
Associate Professor, RCAST, UTokyo
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2002. 04
Professor, RCAST, UTokyo

Research Interests

The objective of our research is to find a new therapeutic strategy for cancer and severe inflammatory diseases through understanding the biological phenomena in dynamic molecular interactions. Our challenges in the quantitative biological approaches are the establishment of FRET (fluorescent resonance energy transfer) probe of GPCR (G-protein coupled receptor) signaling for live cell imaging of chemotaxis, the computer-assisted drug design based on the protein structure and thermodynamic analysis of protein interactions for the cancer treatment, the development of water-window X-ray microscope, the molecular pattern recognition analysis in the host defense mechanism in innate immunity, and the protein – RNA interactions in the regulation of RNA splicing related to the cell cycle control.


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