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Researcher's Profile

2017.09 :  Moving Out

Project Associate Professor

Hiroko IWANARI

Quantitative Biology and Medicine

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Biography

2007.04
Project Assistant Professor, RCAST, The University of Tokyo (UTokyo)
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2014.04
Project Associate Professor, RCAST, UTokyo
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2017.09
Moving Out

Research Interests

We aim to develop new therapeutic and diagnostic methods for treating intractable diseases for which there are currently no effective therapeutic or prophylactic treatments, such as cancer, autoimmune diseases, viral infections, and multiple sclerosis, through elucidation of the mechanisms of these diseases using biochemical and molecular biological approaches. Monoclonal antibodies against proteins involved in the diseases can be used not only as therapeutic drugs in themselves, but also as useful and powerful tools for such elucidation. In order to generate the highly functional monoclonal antibodies, we have taken a systematic approach using a baculovirus display system for the presentation of antigens, and manipulating the immunological tolerance of host animals for the immunization of self-antigens or antigens having a high degree of structural homology with self-antigens. As for the cancer specific antibodies which we previously succeeded in generating, we conduct applied research on the design of these engineered antibodies, for example, multi-specific antibodies, and on establishing a validation system for such artificial antibodies.


Keywords

Monoclonal antibody, Multi-functional antibody, Antibody therapeutics, Diagnostics

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