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Researcher's Profile

Associate Professor

Yoshihiro MATSUMURA

Division of Metabolic Medicine

E-mail: matsumura-y.lsbm.org

Tel: 03-5452-5471

FAX: 03-5452-5429

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Biography

2004.03
PhD, Department of Chemistry, Graduate School of Science, Tohoku University
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2004.06
Postdoctoral researcher, Department of Physiology, Akita University School of Medicine
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2008.01
Postdoctoral researcher, Department of Biochemistry and Molecular Biology, Oregon Health & Science University
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2011.09
Project Research Associate, Division of Metabolic Medicine, RCAST, UTokyo
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2012.04
Research Associate, Division of Metabolic Medicine, RCAST, UTokyo
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2017.04
Associate Professor, Division of Metabolic Medicine, RCAST, UTokyo

Research Interests

Living organisms need to adapt to various environments in order to maintain their life. Cells in our body adapt to various environments by utilizing genome, protein networks, metabolic system, as well as epigenome. “Epigenome”, genetic information consisted of DNA methylation and histone post-translational modifications, functions as cellular memories to adapt to external environments. Adipocytes, which stores excess energy as lipids, have been originally developed to protect life from starvation and coldness. However, in convenient modern society where civilization has advanced, adipocytes often become unable to play normal physiological function, and impaired function of adipocytes is a pathogenesis of life-style diseases such as diabetes and hyperlipidemia. In order to understand mechanisms in adipocytes for adaptation to nutritional environment and coldness, we utilize systems biology approach and analyze transcriptome, epigenome, metabolome, and proteome in adipocytes. By understanding of mechanisms in adipocytes for adaptation to environments, we will be able to improve body constitution such as abilities to store and burn fat. Our research will develop novel strategy to prevent and treat metabolic syndrome.


Keywords

Adipocytes, Epigenome, Metabolism, Environmental adaptation, Metabolic syndrome

Edudational Systems

  • Department of Advanced Interdisciplinary Studies, Graduate School of Engineering

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