Start Global Navigation

  1. Home
  2. About RCAST
  3. Research
  4. Industry-Academia-Government Collaboration
  5. International Collaboration
Research

Start Main Contents

Researcher's Profile

Project Professor

Toshiya TANAKA

System Biology and Medicine

E-mail: tanaka.lsbm.org

Office:

Tel: 03-5452-5025

FAX: 03-5452-5025

outer link Laboratory Homepage

inner link 2017 Research book

Biography

1993.03
M.S. Tokyo University of Pharmacy and Life Science
Line
1993.04
Research & Development Divisiton, Grelan Pharmaceutical Co., Ltd.
Line
2004.09
Ph.D. The University of Tokyo(UTokyo)
Line
2004.10
Project Assistant Professor, RCAST, UTokyo
Line
2006.02
Project Associate Professor, RCAST, UTokyo
Line
2007.04
Project Associate Professor, RCAST, UTokyo
Line
2015.04
Project Professor, RCAST, UTokyo

Research Interests

Nuclear receptors (NRs) are ligand-dependent transcription factors directly controlling gene expression in response to a wide range of developmental, physiological, and environmental cues. It has been recognized that the apparent implication of certain orphan NRs in various metabolic disorders, e.g. atherosclerosis and diabetes, drug interaction, and cancer proliferation, might make them excellent targets for drug development. To clarify the physiological function, tissue or cell-specific expression, and ligand-dependent transcriptional complex formation of NRs, we have generated monoclonal antibodies to all members of the human NR family, with which we perform localizome analysis, ChIP-sequencing, and targeted proteomics.
Localizome analysis of nuclear receptors
Protein tissue and cellular localization data provide valuable information helpful in elucidating physiological function. By immunohistochemical analyses, we determine the tissue and cellular localization of all 48 members of NRs protein.
ChIP-sequencing of nuclear receptors
We perform ChIP-sequencing to identify genomic NRs binding sites. This method has the advantage of identifing direct interactions between NRs and their responsive elements.
Targeted proteomics of nuclear receptors
Protein-protein interactions regulate NRs transcriptional activity and their target genes expression levels. We utilize a shotgun proteomics technique to identify NRs complex formation.



Start Site Information

page top

Copyright (c) RCAST, The University of Tokyo