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Researcher's Profile

Professor

Youichiro WADA

System Biology and Medicine

Biography

1992.03
Medical School, The University of Tokyo(UTokyo)
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1992.12
Assistant professor, ICU, Ichihara Hospital, Teikyo University
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1994.01
MD, Yokohama Rosai Hospital
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1995.04
MD, Internal Medicine, UTokyo Hospital
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1999.03
Research Associate, Komaba Open Laboratory, UTokyo
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2003.04
Visiting Researcher, Beth Israel Deaconess Medical Center, Harvard University
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2007.12
Research Associate, RCAST, UTokyo
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2010.04
Project Associate Professor, RCAST, UTokyo
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2013.04
Professor, Radioscope Center, UTokyo

Research Interests

In vascular system, endothelial cell has an important role in responding and adapting to various environmental stimulation including hypoxia, modif ied lipid, and inf lammation. Atherosclerosis is considered as a result of bankrupt of this adaptation system. Formerly these findings were observed by comprehensive gene expression analysis using microarray. In these days, combination of chromatin immuno-precipitation and de ep s equencing enable s us to obs er ve dynamic movement of chromatin by identifying localization of histone modification, polymerase binding, and special proximity in whole genome manner. Based on the finding obtained by gene expression analysis, we are trying to clarify the mode of action of RNA polymerase II, which transcribe genomic DNA and generate RNA. Unexpectedly, our findings did not fit to the linear sliding model, which was established from bacteria research. Our data suggested not free single polymerase but organized multiple polymerases pull DNA of necessity into hot spot and perform transcription, as was proposed as "factory hypothesis" by Cook in 1981. Currently, we are focusing to clarify the identity of this transcription factory complex, and elucidate the mechanism of dynamic movement of chromatin in response to inflammatory stimulation. Transcription is one of the most fundamental phenomena, which is beyond the power of microscopy, and we are trying to dissect this by virtue of latest experimental technology, informatics method, and international collaboration.


Keywords

epigenome, chromatin structure, transcription, vascular biology, radiation biomedicine, cardiovascular medicine

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