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Bioorganic Chemistry Okamoto Laboratory

'Biomolecular design' : Borderless research between organic synthesis and life science

Synthetic chemistry enables us to explore the frontiers of cell biology

As we investigate biological questions of increasing complexity, new chemical technologies can provide atoms-level views of cellular function. The focus is on the molecular design, synthesis and physical properties of new, man-made biopolymers with various functions. Also included is the design of unprecedented organic chemical systems for recognizing and visualizing a single component or atom in biopolymers of interest.

(1)Chemistry creating nucleic acids

Nucleic acid is a key molecule that controls vital functions. We create novel chemical reactions and functional biopolymers to specifically recognize the epigenetic modification of nucleic acids. We also pursue the highly functional photochemistry to visualize nucleic acid function in the cell.

(2)Chemistry building proteins

Protein significantly changes its function by posttranslational modifications. We chemically synthesize proteins and peptides with a variety of posttranslational modifications. We also develop novel chemical reactions to specifically recognize/visualize posttranslational modifications.

(3)Chemistry controlling cell function

Cell functions may be controlled by sophisticated molecular design.
We create new molecular systems controlling a specific cell function by chemically wrapping biomolecules and cells and unwrapping them by an external stimulus.

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Staining specific intracellular nucleic acids by our chemical probes
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Chemically synthesizing super proteins which cells cannot create
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Wrapping a cell by with stimuli-responsive hydrogels: 'cell tablet'

Member

  • Akimitsu OKAMOTO
  • Specialized field:Bioorganic chemistry, Organic synthesis, Photobiochemistry, Nucleic acid chemistry, Epigenetics
  • Satoshi YAMAGUCHI
  • Specialized field:Bioorganic chemistry, Chemical bioengineering
<As of May 2020>
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