Researcher's Profile

  • Project Associate Professor
  • Takeshi MARUMO
  • Clinical Epigenetics

Biography

March 1990 MD, Keio University School of Medicine
April 1990 Doctor course, Keio University School of Medicine
January 1996 Postdoctoral Fellow, Frankfurt University (Humboldt Foundation)
December 1998 Head Physician, Inagi Municipal Hospital
November 2002 Project Assistant Professor, The University of Tokyo (UTokyo)
November 2011 Lecturer, Kyorin University
December 2012 Project Lecturer, RCAST, UTokyo
May 2015 Project Associate Professor, RCAST, UTokyo
December 2019 Move out
     

Research Interests

The number of patients suffering from cardiovascular disease and chronic kidney disease caused by hypertension and diabetes is increasing despite of the development of many effective drugs. Moreover, means to cure patients with hypertension, diabetes and their complications are still unavailable. We hypothesize that epigenetic mechanisms, such as histone modification and DNA methylation, underlie the irreversible nature of hypertension, diabetes and their complications. Because DNA methylation is maintained in daughter cells after cell division, phenotypic changes of organs based on epigenetic abnormalities caused by hypertension and diabetes can also be maintained. We think that abnormal epigenetic modifications are the target of novel therapy for hypertension and diabetes.
Because each cell population in the kidney has distinct DNA methylation pattern, we collect the specific cell population by using cell sorter for the analysis of epigenetic modifications. We found that the expressions of some transporters are strictly regulated by DNA methylation in proximal tubule cells in the kidney. We are now studying the abnormal DNA methylation potentially involved in the development of diabetic nephropathy.

Keywords

diabetes, hypertension, chronic kidney disease, epigenetics

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