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Researcher's Profile

  • Associate Professor
  • Yoshihiro MATSUMURA
  • Metabolic Medicine
E-mail
matsumura-ylsbm.org
Tel
03-5452-5471
FAX
03-5452-5429
URL

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URL

Biography

March 2004 PhD, Department of Chemistry, Graduate School of Science, Tohoku University
June 2004 Postdoctoral researcher, Department of Physiology, Akita University School of Medicine
January 2008 Postdoctoral researcher, Department of Biochemistry and Molecular Biology, Oregon Health & Science University
September 2011 Project Research Associate, Division of Metabolic Medicine, RCAST, UTokyo
April 2012 Research Associate, Division of Metabolic Medicine, RCAST, UTokyo
April 2017 Associate Professor, Division of Metabolic Medicine, RCAST, UTokyo

Research Interests

Living organisms need to adapt to various environments in order to maintain their life. Cells in our body adapt to various environments by utilizing genome, protein networks, metabolic system, as well as epigenome. “Epigenome”, genetic information consisted of DNA methylation and histone post-translational modifications, functions as cellular memories to adapt to external environments. Adipocytes, which stores excess energy as lipids, have been originally developed to protect life from starvation and coldness. However, in convenient modern society where civilization has advanced, adipocytes often become unable to play normal physiological function, and impaired function of adipocytes is a pathogenesis of life-style diseases such as diabetes and hyperlipidemia. In order to understand mechanisms in adipocytes for adaptation to nutritional environment and coldness, we utilize systems biology approach and analyze transcriptome, epigenome, metabolome, and proteome in adipocytes. By understanding of mechanisms in adipocytes for adaptation to environments, we will be able to improve body constitution such as abilities to store and burn fat. Our research will develop novel strategy to prevent and treat metabolic syndrome.

Keywords

Adipocytes, Epigenome, Metabolism, Environmental adaptation, Metabolic syndrome

Edudational Systems

  • Department of Advanced Interdisciplinary Studies, Graduate School of Engineering

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