Researcher's Profile

Professor
Ayuko HOSHINO
Intercellular Communication & Medical Science

E-mail: aynhoshinog.ecc.u-tokyo.ac.jp

URL: Laboratory Homepage

URL: 2023 Research Book (PDF:1.1MB)

Biography

March 2006	B.Sc. in Chemistry, Tokyo University of Science
March 2008	M.Sc. in Cell and Molecular Biology, The University of Tokyo (UTokyo)
March 2011	Ph.D. in Cell and Molecular Biology, UTokyo
March 2011	Postdoctoral Associate, Weill Cornell Medicine, New York
April 2013	JSPS Postdoctoral Fellow for Research Abroad
April 2015	Research Associate, Weill Cornell Medicine, New York
April 2016	Instructor, Weill Cornell Medicine, New York
April 2019	Lecturer, IRCN, UTokyo
March 2020	Associate Professor, Tokyo Institute of Technology
May 2020	Bioinformatics Advanced Certificate, New York University Tandon School of Engineering
March 2023	Professor, RCAST, UTokyo

Research Interests

Exosomes, which are produced by all cells, have been suggested to be involved in various diseases. In Hoshino laboratory, we hope to unravel the influence of exosomes in causing cancer progression, pregnancy complication, onset and etiology of autism, as well as other neurodegenerative diseases. We look forward to working together to elucidate exosome driven disease pathology and develop novel treatments.

Exosome in disease etiology and detection
We are investigating how exosomes are involved in the pathogenesis and progression of various diseases such as cancer, preeclampsia, autism spectrum disorder, schizophrenia, and Alzheimer's disease. From the analysis and data obtained by elucidating the relationship between exosomes and various diseases, we also aim to clarify the role of exosomes under normal conditions.

Deciphering exosome heterogeneity
Exosomes have been found to have a highly diverse population, due to the molecules contained, size, membrane charge, etc. We aim to decode these differences by examining single exosomes as well as understanding the biogenesis of exosomes.

Exosome in disease etiology and detection

Inter-organ communication of exosomes

Award

2011　Keystone Symposia Scholarship Award
March 2011　Excellent thesis award 2011 of The University of Tokyo
2020　The 22nd Morita Encouragement Award for Young Women Scientists
November 2020　The 2nd Brilliant Female Researchers Award (The JST President Award)
December 2020　Tokyo Tech Research Festival Best Presenter Award
February 2021　Interstellar Initiative Healthy Longevity Award
April 2021　The Young Scientists’ Award The Commendation for Science and Technology by the Minister of Education, 　　Culture, Sports, Science and Technology
July 2021　Tokyo Tech Suematsu Challenging Research Award
September 2021　NAM 2021 International Catalyst Award
September 2021　Frontier Salon Nagase Grand Prize
November 2021　The Award of Ohsumi Life Science Research Society for Young Scientist
December 2021　Takeda Young Investigator Award
February 2022　The 18th JSPS Prize
April 2022　27th Society of Japanese Women Scientists Award
September 2022　NAM Healthy Longevity QuickFire Challenge Award - Accelerator Award -
October 2022　The 6th Bioindustry Research Award
October 2022　Forbes JAPAN WOMEN AWARD 2022 Change Maker Award

Keywords

Exosome, Autism Spectrum Disorder, Pregnancy Complications, Cancer, Metastasis, Disease Biology, Inter-organ Communication

Educational Systems

Department of Advanced Interdisciplinary Studies, Graduate School of Engineering