Researcher's Profile

  • Professor
  • Ayuko HOSHINO
  • Intercellular Communication & Medical Science

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March 2006 B.Sc. in Chemistry, Tokyo University of Science
March 2008 M.Sc. in Cell and Molecular Biology, The University of Tokyo (UTokyo)
March 2011 Ph.D. in Cell and Molecular Biology, UTokyo
March 2011 Postdoctoral Associate, Weill Cornell Medicine, New York
April 2013 JSPS Postdoctoral Fellow for Research Abroad
April 2015 Research Associate, Weill Cornell Medicine, New York
April 2016 Instructor, Weill Cornell Medicine, New York
April 2019 Lecturer, IRCN, UTokyo
March 2020 Associate Professor, Tokyo Institute of Technology
May 2020 Bioinformatics Advanced Certificate, New York University Tandon School of Engineering
March 2023 Professor, RCAST, UTokyo

Research Interests

Exosomes, which are produced by all cells, have been suggested to be involved in various diseases. In Hoshino laboratory, we hope to unravel the influence of exosomes in causing cancer progression, pregnancy complication, onset and etiology of autism, as well as other neurodegenerative diseases. We look forward to working together to elucidate exosome driven disease pathology and develop novel treatments.

Exosome in disease etiology and detection
We are investigating how exosomes are involved in the pathogenesis and progression of various diseases such as cancer, preeclampsia, autism spectrum disorder, schizophrenia, and Alzheimer's disease. From the analysis and data obtained by elucidating the relationship between exosomes and various diseases, we also aim to clarify the role of exosomes under normal conditions.

Deciphering exosome heterogeneity
Exosomes have been found to have a highly diverse population, due to the molecules contained, size, membrane charge, etc. We aim to decode these differences by examining single exosomes as well as understanding the biogenesis of exosomes.

  • Exosome in disease etiology and detection
  • Exosome in disease etiology and detection
  • Inter-organ communication of exosomes
  • Inter-organ communication of exosomes


  • 2011 Keystone Symposia Scholarship Award
  • March 2011 Excellent thesis award 2011 of The University of Tokyo
  • 2020 The 22nd Morita Encouragement Award for Young Women Scientists
  • November 2020 The 2nd Brilliant Female Researchers Award (The JST President Award)
  • December 2020 Tokyo Tech Research Festival Best Presenter Award
  • February 2021 Interstellar Initiative Healthy Longevity Award
  • April 2021 The Young Scientists’ Award The Commendation for Science and Technology by the Minister of Education,   Culture, Sports, Science and Technology
  • July 2021 Tokyo Tech Suematsu Challenging Research Award
  • September 2021 NAM 2021 International Catalyst Award
  • September 2021 Frontier Salon Nagase Grand Prize
  • November 2021 The Award of Ohsumi Life Science Research Society for Young Scientist
  • December 2021 Takeda Young Investigator Award
  • February 2022 The 18th JSPS Prize
  • April 2022 27th Society of Japanese Women Scientists Award
  • September 2022 NAM Healthy Longevity QuickFire Challenge Award - Accelerator Award -
  • October 2022 The 6th Bioindustry Research Award
  • October 2022 Forbes JAPAN WOMEN AWARD 2022 Change Maker Award


Exosome, Autism Spectrum Disorder, Pregnancy Complications, Cancer, Metastasis, Disease Biology, Inter-organ Communication

Educational Systems

  • Department of Advanced Interdisciplinary Studies, Graduate School of Engineering

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