Synthetic Biology

School of Biomedical Engineering,
The University of British Columbia

DNA event recording biology

While early mammalian embryogenesis can be observed at the single-cell resolution under a microscope, a cell division lineage of whole-body development is yet to be resolved. The continuous turnover and response of cells during homeostasis, as well as in many disorders, also remain unclear. At present, no technology enables efficient analysis of dynamic changes in molecular profiles and cellular behaviors in complex biological systems. We are developing “DNA event recording” technologies, by which highresolution molecular and cellular information of individual cells in a multicellular organism can be progressively stored in cell-embedded synthetic “DNA tapes.” At the time of observation, such a system allows the readout of historical molecular and cellular information of many cells using high-throughput DNA sequencing.

Member

• 
• • Visiting Associate Professor
    Nozomu YACHIE
  Specialized field: Mammalian synthetic biology

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