Genome Science & Medicine

Dissect biomedical phenomena with advanced genomic technologies

Personal cancer genome

The variety of genetic and epigenetic alterations that accumulate in cancer genomes cause activation of oncogenes and inactivation of tumor suppressor genes, leading to cellular transformation. Next generation sequencing technology has enabled us to obtain individual genomic information within feasible cost and time constraints. Since 2008 my group has participated in the International Cancer Genome Consortium and is studying the genomic alterations in liver and gastric cancers.

Chromatin regulation

Epigenetic processes are essential for the packaging and interpretation of the genome, fundamental to normal development and cell differentiation, and increasingly recognized as being involved in human disease. Epigenetic mechanisms, which include histone modification, positioning of histone variants, nucleosome remodeling, DNA methylation, and non-coding RNAs, are considered as “cellular memory”. We have applied genomic technologies, such as ChIP-sequencing and chromatin interaction, to map these epigenetic marks and high-order structure throughout the genome and to elucidate how these marks are written and read.

Translational research

Functional genomic approaches are applied to identify novel biomarkers for disease diagnostics and therapeutics.

Member

• 
• • Senior Research Fellow
    Hiroyuki ABURATANI
  Research Area : Genomic Medicine

• 
• • Project Associate Professor
    Genta NAGAE
  Research Area : Genomic Medicine

• 
• • Project Associate Professor
    Kenji TATSUNO
  Research Area :Cancer Genome Analysis, Gene Panel Test,Precision Medicine

Laboratory Homepage