Department of Inflammology
Social Cooperation Research Departments
Development of novel therapeutic agents for inflammatory diseases and cancer by targeting self-derived molecules
Induction of inflammation is essential for maintenance of host homeostasis. However, chronic or excessive inflammation exacerbates the pathogenesis of metabolic diseases and cancer. We are focusing on damage-associated molecular patterns (DAMPs; also known as Alarmin) released from damaged or dying cells and studying the relationship between immune responses induced and regulated by DAMPs and diseases. DAMPs have been reported to activate innate immune receptors and cause inflammation. Using molecular biological techniques and advanced omics analysis, we have identified new DAMPs that are involved in the formation of the tumor immune microenvironment. We are also working on the development of nucleic acid type drugs and antibodies targeting DAMPs. Through these studies, we aim to overcome diabetes and cancer.
- Promotion of tumor immune microenvironment by tumor dead cell-derived molecule
- Using cell labeling systems in the tumor microenvironment, we are trying to elucidate novel cell-cell interactions that modulate tumor immunity.
Cooperation Company/Organization
・Boostimmune Inc.
Member
Project Associate Professor
Hideyuki YANAI
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