Researcher's Profile

  • Fellow
  • Toshiro FUJITA
  • RCAST Fellow
E-mail
Toshiro.fujitarcast.u-tokyo.ac.jp
Tel
03-5452-5070
FAX
03-5452-5069

Biography

March 1972 Graduated from Keio University School of Medicine
January 1977 Visiting Scientist, National Institutes of Health
July 1978 Assistant Professor, Department of Internal Medicine, University of Tsukuba
April 1988 Assistant Professor, Fourth Department of Internal Medicine, The University of Tokyo (UTokyo) School of Medicine
June 1989 Associate Professor, Fourth Department of Internal Medicine, UTokyo School of Medicine
March 1995 Professor, Fourth Department of Internal Medicine, UTokyo School of Medicine
April 1997 Professor, Department of Nephrology and Endocrinology, Graduate School of Medicine, UTokyo
April 2012 Project Professor, Division of Clinical Epigenetics, RCAST, UTokyo
June 2012 Emeritus Professor, UTokyo
April 2018 Distinguished Research Professor, Shinshu University
April 2018 Fellow, RCAST, UTokyo 
             

Research Interests

Our laboratory has continuously been trying to clarify the pathophysiology of lifestyle diseases and to discover effective countermeasures to restore health. Our recent project has centered around the mechanisms of hypertension and organ damage induced by excess salt. We have found that a small GTPase, Rac1, activates the mineralocorticoid receptor (MR) which regulates the internal sodium balance and blood pressure, independently from aldosterone. We have also shown that an aberrant Rac1-MR pathway is involved in the development of salt-induced hypertension. Activation of hypothalamic-renal sympathetic nervous system is also participated in obesity-induced salt-sensitive hypertension, through the activation of β-adrenergic-NCC pathway, which increases the reabsorption of sodium in the renal tubules. Accordingly, an epigenetic mechanism plays an important role in the prenatal programmed salt-sensitive hypertension evoked by hypothalamic-renal sympathetic overactivity (DOHaD hypothesis). Recently, our group found that salt-induced activation of vascular Wnt5a-RhoA pathway under the anti-aging factor Klotho deficiency is involved in aging-associated salt-sensitive hypertension. Thus, the salt-sensitivity of blood pressure in individuals is modulated by environmental factors in life; infancy to the elderly. Our goal is to systematically elucidate the mechanism for the epigenetic regulation of gene transcription in salt-induced hypertension. Moreover, epigenetics is known to be involved in the progression of organ damage, and our intriguing mission is to elucidate the mechanism and apply this knowledge to the development of new therapies.

Award

  • November 2019 Homer W. Smith Award

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