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- Tadatsugu TANIGUCHI
Researcher's Profile
- Fellow
- Tadatsugu TANIGUCHI
- RCAST Fellow
Biography
November 1978 | Member, Cancer Institute, Japanese Foundation for Cancer Research |
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October 1979 | PhD, University of Zurich |
April 1984 | Professor, Institute for Molecular and Cellular Biology, Osaka Uiversity |
January 1995 | Professor, The University of Tokyo (UTokyo) School of Medicine |
April 2012 | Project Professor, Institute of Industrial Science, UTokyo |
April 2019 | Advisor to the Office of President, The University of Tokyo |
April 2021 | Fellow, RCAST, UTokyo |
Research Interests
My work principally concerns the mechanisms of signal transduction and gene expression that underlie immunity and oncogenesis. Many of his research projects have stemmed from his original discovery of two cytokine genes, interferon-beta and interleukin-2. These discoveries have laid the groundwork for the molecular characterization of the various systems of cytokines as well as therapeutic advances achieved by the administration of cytokines. One extension of this research was his discovery of a new family of transcription factors, the interferon regulatory factors (IRFs), which he and others have since identified as playing integral roles in the regulation of the immunity, inflammation and cancer. My curent interest is to clarify underlying mechanisms of how the immune system affects cancer.
Keywords
Inflammmation, Immunity, Cancer