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Metabolic Medicine Sakai Laboratory

Comprehensive analyses of the external cue and epigenomic modulators in browning of fat cells

New therapeutic approaches for Metabolic syndrome by analyzing Epigenome and metabolome

Obesity and various metabolic disturbance including type 2 diabetes, insulin resistance, atherosclerosis and lipid disorders are epidemic health problem in 21 century. These disorders are also called "life style diseases" and closely related to the environmental cue as well as genetic background. Environmental stimuli are recorded on DNAs and histones as chemical modification such as methylation and epigenomic changes are considered to be closely related to the development of life style diseases. We are currently trying to reveal alterations of epigenome and metabolome by environment and nutritional cue such as cold exposure or fasting that may relate to the new therapy for metabolic disturbance.

To accomplish this purpose,
(1) We are analyzing metabolic signaling and epigenomic changes under fasting.
(2) Epigenomic and metabolomics analyses in fat cell differentiation.
(3) Analyze epigenomic changes under cold exposure and reveal the signaling and the mechanisms for "inducible Brown fat cells in white fat cells" also referred to as "Beige fat cells" that highly express thermogenic genes and actively burn fat for thermogenesis.

We are particularly focusing on posttranslational modification of epigenomic modifiers and exploring new approaches for the treatment and prevention of life style diseases.

Comprehensive analyses of the external cue and epigenomic modulators in browning of fat cells
Comprehensive analyses of the external cue and epigenomic modulators in browning of fat cells
Exploring the therapeutic target for inducing“ Beige” fat cells that burn fat for thermogenesis

 

Exploring the therapeutic target for inducing“ Beige” fat cells that burn fat for thermogenesis

Member

  • Juro SAKAI
  • Specialized field:Nutritional metabolic medicine
  • Yoshihiro MATSUMURA
  • Specialized field:Molecular cell biology, Systems biology, Epigenetics
<As of May 2019>

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