Metabolic Medicine
Sakai Laboratory

Tohoku University Graduate School
of Medicine, Division of Molecular
Physiology and Metabolism

Comprehensive analyses of the external cue and epigenomic modulators in browning of fat cells

Understanding Lifestyle Diseases through Epigenomics
Obesity is a major cause of lifestyle diseases such as type 2 diabetes, hypertension, and coronary artery disease. Our goal is to elucidate the mechanisms of obesity and develop groundbreaking treatments for lifestyle diseases by focusing on modifications to genes (epigenomic changes) caused by environmental stimuli through single-cell analysis, clinical data analysis, and central nervous system manipulation.

Main research areas:

• (1) Elucidating the epigenome that determines adipocyte differentiation.
• (2) Elucidating the mechanism by which cold stress induces beige adipocytes specialized in fat decomposition.
• (3) Elucidating the mechanism by which inherited epigenomes from parents induce beige adipocytes.

• 
• Adaptation to Chronic cold stress via stepwise epigenetic mechanism

メンバー

• 
• • Visiting Professor
    Juro SAKAI
  Specialized field: Nutritional metabolic medicine

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