Metabolic Medicine Sakai Laboratory
New therapeutic approaches for Metabolic syndrome by analyzing Epigenome and metabolome
Obesity and various metabolic disturbance including type 2 diabetes, insulin resistance, atherosclerosis and lipid disorders are epidemic health problem in 21 century. These disorders are also called “life style diseases” and closely related to the environmental cue as well as genetic background. Environmental stimuli are recorded on DNAs and histones as chemical modification such as methylation and epigenomic changes are considered to be closely related to the development of life style diseases. We are currently trying to reveal alterations of epigenome and metabolome by environment and nutritional cue such as cold exposure or fasting that may relate to the new therapy for metabolic disturbance.
To accomplish this purpose,
（1） We are analyzing metabolic signaling and epigenomic changes under fasting.
（2） Epigenomic and metabolomics analyses in fat cell differentiation.
（3） Analyze epigenomic changes under cold exposure and reveal the signaling and the mechanisms for “inducible Brown fat cells in white fat cells” also referred to as “Beige fat cells” that highly express thermogenic genes and actively burn fat for thermogenesis.
We are particularly focusing on posttranslational modification of epigenomic modifiers and exploring new approaches for the treatment and prevention of life style diseases.
Specialized field：Nutritional metabolic medicine
Specialized field：Molecular cell biology, Systems biology, Epigenetics