Chemical Biotechnology
Suga Laboratory
Department of Chemistry,
Graduate School of Science,
Bioorganic Chemistry
Pseudo-natural Peptide Therapeutics
Our laboratory pursues research programs bridging between chemistry and biology. To conduct a good balance of science and technology will build new technologies that contribute to the chemical biology field, covering from basic research to applied research. The following programs are currently active in our laboratory: (1) Non-traditional peptide therapeutics, (2) Engineering the translation system, and (3) Ribosomal synthesis of natural product-like molecules by the combination of the genetic code reprogramming and post-translational modifying enzymes, (4) Grafting of cyclic peptide’ s pharmacophore, “LassoGrafting” , to designated loops of proteins to generate non-traditional therapeutical biologics. Dr. Suga is the laureate of Wolf Prize 2023 and Japan Academy Prize 2024.
X-ray crystal structures of the complex of target protein with pseudonatural peptides generated by the RaPID system
Member
-
- Professor
Hiroaki SUGA
Research Area: Chemical biology, Bioorganic chemistry - Professor
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