Structural Bioengineering
Kato Laboratory
Seeing, Knowing, and Creating Proteins –Connecting Micro-level Understanding to New Biotechnology–
Proteins, the building blocks of life, have evolved over millions of years to perform a myriad of functions. Our laboratory is dedicated to understanding the molecular basis of these functions and harnessing this knowledge to develop groundbreaking biotechnologies. By integrating state-of-the-art techniques such as cryo-electron microscopy, artificial intelligence, electrophysiology, and molecular pharmacology, we aim to push the boundaries of protein research and contribute to the advancement of the field.
Our current research focuses on three key areas:
1. Elucidating light-sensing mechanisms and advancing optogenetic technologies
We investigate the molecular mechanisms by which organisms perceive and respond to light, and apply this understanding to develop sophisticated optogenetic tools for manipulating biological processes with unprecedented precision.
2. Deciphering magnetic sensing mechanisms and establishing magnetogenetics
Our lab is at the forefront of unraveling the enigmatic mechanisms of magnetic field perception in organisms such as migratory birds. By understanding these processes at the molecular level, we aim to establish a novel field of magnetogenetics, enabling the control of biological systems using magnetic fields.
3. Investigating diverse physicochemical stimulus sensing and developing novel technologies and drug discovery platforms
We conduct comprehensive structural and functional analyses of proteins that are activated by a wide range of physicochemical stimuli, including hormones, neurotransmitters, odorants, pH, pressure, and temperature (e.g. GPCRs). By leveraging these insights, we seek to develop innovative technologies and identify novel drug targets for treating various human diseases.
1. Research in Kato Lab
2. Structural analysis of physicochemical receptors
3. Development of novel optogenetics tools
Day in and day out, I find myself captivated by the incredible ways in which living organisms harness a diverse array of proteins, such as GPCRs, (non-GPCR) rhodopsins, PYP, cryptochromes, and TRP channels, to convert a wide range of physicochemical stimuli – from light and magnetism to heat and odorant molecules – into forms that can be seamlessly integrated into their biological processes. Although my busy schedule has recently prevented me from finding time to conduct experiments myself, engaging in discussions about data and projects with my students and postdocs has become a daily source of inspiration and motivation. In my personal life, I used to be a night owl, typically waking up at 9 AM and going to bed around 3 AM the following morning. However, recent changes in my living situation have surprisingly transformed me into a morning person, with my current routine involving waking up at 7 AM and heading to bed around midnight. When I am not in the lab, I enjoy exploring new cafes, going boat fishing, and engaging in stimulating conversations about science over delicious food and drinks.
Member
-
- Professor
Hideaki Kato
Research Area: Structural Biology, Protein engineering, rhodopsins, GPCRs, optogenetics, magnetogenetics - Professor
Laboratory Homepage
Tags
