Integrative Nutriomics and Oncology
Osawa Laboratory

Understanding cancer biology by comprehensive nutriomics approach to establish novel anti-cancer strategies

Integration of “nutriomics” and oncology for the treatment of cancer

Based on the conventional nutritional notion, carbohydrates, lipids and amino acids were independently considered in cancer. However, recent researches in cancer metabolism have been dramatically improved our metabolic knowledge of these disorders due to latest understanding of cancer metabolism. Indeed, carbohydrates, lipids and amino acids are inter-connected in the metabolic pathways, through the several key metabolic molecules such as acetyl-CoA and ketone body intermediates partly under epigenetic regulation.
Our group reported that hypoxia, nutrient starvation, acidic pH may induce tumor aggressiveness by epigenetic regulation in cancer cells. We found that epigenetic and metabolic changes influence cancer progression in cell-cell interaction, single cell, organelle level that can be utilizes for the development of novel therapies by integration of genome, epigenome, transcriptome, proteome, metabolome analysis.

Our research objectives:

• （1）To understand the mechanism of cancer adaptation in carbohydrate/lipids/amino acids deficiency and apply it to therapy.
• （2）Latest understanding of “nutriomics” and nuclear receptor medicine for treatment of cancer and metabolic diseases.
• （3）Drug discovery based on physics and computational science.

We challenge to develop therapeutics for metastasis and recurrent advanced cancer through the viewpoint of integrative “multiomics” approach.

Member

• 
• • Associate Professor
    Tsuyoshi OSAWA
  Specialized field: Cancer Metabolism, Systems Oncology, Vascular Biology

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