Integrative Nutriomics and Oncology
Osawa Laboratory
Understanding cancer biology by comprehensive nutriomics approach to establish novel anti-cancer strategies
Identification of novel cancer metabolite to promote cancer
Cancer cells accumulate physiologically active cancer metabolites (known as oncotabolites) according to the extreme tumor microenvi-ronments and contribute to aggressiveness of canccer such as cancer proliferation, invasion and metastasis. We aimed to identify unknown oncometabolites and examine their roles in cancer cells.
Understanding cancer metabolism in tumor microenvironments
Cancer cells acquire malignancy in extreme tumor microenvironments such as hypoxia, nutrient deprivation and acidic pH. Our goal is to elucidate multi-layer cancer metabolic adaptations against carbohy-drates, lipids and amino acids that have been studied by independent paradigms.
Development of cancer therapies through comprehensive "Nutriomics" approach
Upon integration of genome, epigenome, transcriptome, proteome, and metabolome data through the comprehensive “Nutri-Omics” approach, we try to clarify the transcriptional-metabolic system in cancer cells accompanying tumor microenvironments, leading to the development of novel anti-cancer treatments.
Integrative Nutriomics approach to overcome cancer
Cell-Cell interaction-Single cell-Organella analysis
Dynamics of nuclear receptor on DNA
In the Osawa Laboratory, we focus on identifying bioactive cancer metabolites that contribute to malignancy and elucidating the cancer metabolic adaptation system within the tumor microenvironment. By integrating multi-layered omics information—genomics, epigenomics, transcriptomics, proteomics, and metabolomics—we approach our research from a nutrigenomics perspective to develop novel cancer therapies.
We are also advancing research on the control mechanisms of cellular organelles affected by metabolic fluctuations, aiming to understand life phenomena at the organism, single-cell, and organelle levels.
In the Osawa Lab, teachers and students from various fields come together, bringing diverse perspectives and enjoying their daily research activities. Would you like to join us in research that leads to the development of new cancer therapies? We welcome inquiries from anyone interested in our laboratory, research topics, or collaborative research.
Member
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- Associate Professor
Tsuyoshi OSAWA
Research Area: Cancer Metabolism, Systems Oncology, Vascular Biology - Associate Professor
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